Johanna

You can create value with breakthrough innovation, incremental refinement, or complex coordination. Great companies often do two of these. The very best companies do all three.

To show how this might work, let’s take multiple sclerosis as an example. It is a devastating condition in need of better therapies. When testing new drugs in animal studies, researchers measure and report a number of different metrics, including the effects of drug candidates on inflammation, on damage to nerve fibres (axon loss), on damage to the... See more

Basically, this boils down to “use your personal networks more”. By at least a 10x margin, the best candidate sources I’ve ever seen are friends and friends of friends.

A great team and a great market are both critically important—you have to have both. The debate about which is more important is silly.

No problem is too small or too trivial if we can really do something about it.

Whenever possible i recommend contract-to-hire for remote teams.Get them on for 1-2 weeks on a specific project. This will tell you more about them than any whiteboarding tests you will ever do.

After two years of working from home, I don’t have one unified period of getting things done. I have several mini periods. Work isn’t a contiguous landmass of focus; it’s more like an archipelago of productivity amid a sea of chores, meals, mental breaks, and other responsibilities.