How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence

Led by public figures like Michael Pollan, Tim Ferriss, and even Joe Rogan, and leading institutions like Johns Hopkins, NYU, Berkeley, and Imperial College London, therapeutic psychedelics are going mainstream again

It is known that the likelihood of long-term therapeutic gains increases with the likelihood of the subject having a mystical experience, prima facie evidence favoring a critical role for subjectivity. It is precisely the high emotional impact of the memories of the vivid and highly unusual psychedelic experience that serves as the primary source o

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Also, psychedelics have a fundamental discordance with allopathic research which can never be overcome. The placebo problem is unsolvable. And these medicines are customarily adjacent to non-directive therapy, and ongoing integration. We'll never be able to quantify those things in a trial format the same we we can for a blood pressure pill. Finall... See more

One common observation is that psychedelics destabilize longrange cortical communication patterns and reduce activity in the posterior cingulate cortex and precuneus in the posterior regions of the neocortex. This is the compatible with our knowledge of the brains of people trained in mindfulness. It appears that the less these midline structures a

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